Source credit: Journal of Applied Physiology via PubMed. DOI: 10.1152/japplphysiol.00530.2025.
Short Summary
A new systematic review and meta-analysis in Journal of Applied Physiology looked at how exercise changes neutrophil-to-lymphocyte ratio, or NLR, a blood marker often discussed in relation to systemic inflammation. Across 26 studies and 1,203 participants, the review found no meaningful NLR change immediately after acute exercise, a temporary rise one to three hours after exercise, and a small overall reduction after chronic exercise training.
Why it matters for lifters
For lifters, the practical message is not that one blood marker should guide programming on its own. The study supports a more familiar pattern: a hard session can create a short-term stress response, while consistent training may be associated with lower inflammatory-marker levels over time. That matters when interpreting bloodwork near training sessions, especially during high-volume blocks, return-to-training phases, or health-focused programs for older adults.
What to watch next
The review reported high heterogeneity across studies, meaning the size and timing of NLR changes varied widely. Future work needs cleaner comparisons by training mode, intensity, age, health status, and sampling time after exercise. Lifters should also watch whether sports-medicine groups begin offering clearer guidance on when blood tests should be scheduled relative to hard training.
Health Disclaimer
This article is for informational purposes only and is not medical advice. Do not use NLR, inflammation markers, or exercise changes to diagnose or treat a condition without guidance from a qualified health professional.