Central Fatigue Review Finds Serotonin Signals Are Not a Simple Performance Switch

A new JISSN meta-analysis suggests serotonin-related central fatigue signals vary by outcome, reinforcing caution around simple performance-hack claims.
Training articles, exercise technique, programming notes, and workout education.

A new JISSN meta-analysis suggests serotonin-related central fatigue signals vary by outcome, reinforcing caution around simple performance-hack claims.

FDA says PRE-FORMANCE BLACK, a performance product, contained undeclared DMAA. Lifters should treat the notice as a supplement-safety warning, not routine label fine print.

UCLA creatine research points to immune-cell effects in early cancer models, but lifters should not treat it as a treatment shortcut.

A PubMed-indexed resistance-training study found moderate-load lengthened partial knee extensions produced hypertrophy outcomes similar to heavier full range-of-motion work in an eight-week trial.

A JISSN study found caffeine gum paired with resistance priming improved same-day performance markers in male basketball players, but the effect did not persist at 24 or 48 hours.

A Sports Medicine systematic review and meta-analysis found no clear independent hypertrophy boost from higher carbohydrate intake during resistance training, but the certainty of evidence was low.

A Duke-NUS-led study in PNAS points to DEAF1 and mTORC1 as part of the biology that may explain why exercise helps older muscle maintain repair capacity.

A PubMed-indexed study of natural physique athletes suggests post-show recovery should be planned, monitored, and treated as its own training phase.

A randomized trial suggests resistance training plus essential amino acids may improve muscle fitness markers in healthy older women.

Source credit: PubMed – Medicine and Science in Sports and Exercise. Full text is available via PubMed Central. Short summary A PubMed-indexed July 2026 study in Medicine and Science in Sports and Exercise directly compared two common quad-training choices: single-joint…